The relationship between lower urinary tract symptoms and severity of Alzheimer’s disease
Yenman Lu (1)
(1) Department Of Urology, Kaohsiung Municipal Ta-tung Hospital, Kaohsiung, Taiwan
Overactive bladder (OAB) including urinary incontinence (UI) is more prevalent in elderly populations with dementia than without dementia, and Alzheimer’s disease (AD) is the most common cause of dementia. UI may complicate AD morbidity and mortality. Therefore, this study aimed to evaluate if severity of dementia is associated with Lower urinary tract symptoms (LUTs).
A total of 43 AD patients were included in this study. All participants were checked post-void residual (PVR) urine amount after voiding by sonography. The severity of dementia was evaluated by questionnaire including The Cognitive Abilities Screening Instrument (CASI), The Mini-Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR), Clinical Dementia Rating Scale Sum of Boxes (CDR-SB). The LUTs were assessed with The International Consultation of Incontinence Questionnaire (ICIQ), Overactive bladder symptom score (OABSS), Urethral stricture specific questionnaires (USS). We then utilize linear regression analysis to calculate the relationship between them. Age and Gender are constant variable.
The mean age of total 43 AD patients is 78 years old. The scores of CASI are not related to ICIQ, OABSS, USS, PVR (p=0.282, p=0.710, p=0.549, p=0.343; respectively). The relationship between MMSE and ICIQ, OABSS, USS, PVR is not significant (p=0.805, p=0.462, p=0.906, p=0.224; respectively). Furthermore, the different severity of CDR is not related to ICIQ, OABSS, USS, PVR (p=0.340, p=0.627, p=0.171, p=0.279; respectively). Also, the scores of CDR-SB are not related to ICIQ, OABSS, USS, PVR (p=0.107, p=0.577, p=0.118, p=0.202; respectively).
The present results revealed that more severe dementia patients may not have more severe LUTs and more PVR. However, further research with more patients is still necessary to manifest the theory.