The impact of pseudoephedrine and antihistamine on male lower urinary tract symptoms

Short Podium Session

1:30 PM - 2:40 PM

Dr Le-wei Fan (1)

(1) Chang-gung Memorial Hospital, Linkou Branch, New Taipei City, Taiwan

In our earlier study, we investigated the effect of pseudoephedrine on voiding and storage dysfunction in male without previous lower urinary tract symptoms. We found out that IPSS scores increase significantly after medication in patients over age of 50. Now, we liked to not only expand our study number and also compare pseudoephedrine to antihistamine, another medication that was commonly used for treating rhinitis that may cause lower urinary tract symptoms (LUTS). Also, post voiding volume was checked in order for more subjective measurements of voiding function.

AIMS

We prospectively enrolled 200 male patients attending to ENT OPD due to rhinitis, from August 2015 to August 2016. They were then randomized to pseudoephedrine or antihistamine if no contraindication. International Prostate Symptom Score (IPSS score) and post voiding residual urine (PVR) were check before and after one week of treatment. The results were then analyzed with SPSS.

METHODS

There were no significant differences in the characteristic of both pseudoephedrine and antihistamine groups. A trend of increasing IPSS-T, IPSS-V and IPSS-S score were seen in the pseudoephedrine group, however didn’t reached significant. Similar result of IPSS-T and IPSS-V showed in antihistamine group, however not IPSS-S score.

RESULTS

We then divided patients into age ≧ 50 and < 50 years old. There is a significant increase of IPSS-T score in patients ≧50 years old treated with pseudoephedrine, which is not observed in the other antihistamine group. An increase of IPSS-V score were seen in patients age <50 treated with antihistamine.

CONCLUSIONS