Obesity and the prevalence of nocturia in the U.S. population

Non-Moderated Poster Session

12:30 PM - 1:30 PM

Sung Cho (1), Kwang Jin Ko (1), Don Kyoung Choi (1), Ohseong Kwon (1), Young Goo Lee (1), Cheol Young Oh (2)

(1) Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, (2) Hallym University Sacred Heart Hospital, Anyang, South Korea

Nocturia is a highly prevalent and bothersome storage symptom, and is considered to negative impact on quality of life. The pathophysiology of nocturia is varied and difficult to ascertain. There have been many epidemiological studies related to nocturia. Obesity has been shown to be important in the development of nocturia. However, there is little literature to date analyzing the association between obesity and nocturia in a large, nationally representative sample of adults from the United States. Therefore, we investigated the relationship between obesity and nocturia in the U.S. population using The National Health and Nutrition Examination Survey (NHANES) database.

AIMS

Data were collected from the NHANES dataset between 2005 and 2012. NHANES was a cross-sectional data conducted by the Center for Disease Control to determine the health of community dwelling individuals in the US through biannual questionnaires and physical exams. A structured questionnaire was used to investigate nocturia. Study participants were deemed to have nocturia if they answered “two or more” to the following question: “During the past 30 days, how many times per night did you most typically get up to urinate, from the time you went to bed at night until the time you got up in the morning?”

METHODS

A total of 14,135 participants (6,947 men and 7,188 women) from the U.S., aged 20-85 years (mean age=52.5), were analyzed. Among the included participants, 32.7% exhibited the nocturia (men, 30.5%; women, 34.9%). Compared to participants without nocturia, those with nocturia tended to be old and female, and have hypertension, DM and dyslipidemia. In the multivariate logistic regression model, BMI was significantly associated with the prevalence of nocturia (OR: 1.03; 95% CI: 1.02-1.04). The participants who had BMI above 30 kg/m2 had a significantly higher OR for nocturia (OR: 1.41; 95% CI: 1.30-1.53). BMI and obesity was significantly associated with the prevalence of nocturia with 1:1 propensity score matching data with age and sex (BMI; OR: 1.04; 95% CI:1.03-1.05, obesity; OR: 1.57; 95% CI: 1.45-1.71).

RESULTS

Data from the 2005-2012 NHANES, a nationally representative sample, demonstrate that BMI and obesity was significantly associated with the prevalence of nocturia in men and women after taking major confounding factors into account. These findings indicate that greater BMI was significantly associated with increased prevalence of nocturia. Furthermore, it can provide a better underlying mechanisms of nocturia from the observed association between nocturia and obesity.

CONCLUSIONS