Aging independently exacerbates the severity of detrusor overactivity
Dr So Inamura (1), Dr Hisato Kobayashi (1), Dr Akiko Itoga (1), Dr Manami Tsutsumiuchi (1), Dr Masaya Seki (1), Dr Minekatsu Taga (1), Dr Katsuki Tsuchiyama (1), Dr Masato Fukushima (1), Dr Yoshitaka Aoki (1), Dr Hideaki Ito (1), Dr Osamu Yokoyama (1)
(1) University Of Fukui, Department Of Urology, Faculty Of Medical Science, Eiheiji, Japan
We often encounter benign prostatic hyperplasia (BPH) patients with storage dysfunction. In a pressure-flow study (PFS), the existence of detrusor overactivity (DO) is one of the decisive factors of storage dysfunction. We assessed the relative factors of DO in patients with BPH.
We retrospectively analyzed the cases of 120 patients who underwent transurethral surgery for BPH and preoperative PFS from 2006 to 2016. We evaluated the relationship between the patient factors (age, body mass index [BMI], lifestyle diseases, smoking) and the existence of DO. We also assessed the relationship between the bladder capacity at initial DO and clinical parameters.
The age of the patients with DO was significantly older than that of the patients without DO. There was no relationship between the existence of lifestyle diseases and DO. The bladder capacity at initial DO was negatively correlated with age, BMI, and the duration of smoking. The degree of bladder outlet obstruction was not related to DO. In a multivariate analysis, aging was the only independent relative factor of the existence of DO.
Our findings demonstrated that aging is an important factor affecting detrusor overactivity. It was reported that aging was a trigger of aberrant urothelial function, increased afferent mechanosensitivity, and increased smooth muscle contractility . Taken together, the results of our present analyses could be explained by these mechanisms. Further studies are required to reveal the true mechanism of DO.